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At the same time, however, we observed that EV lesions are heavily infiltrated with inflammatory immune cells, which is similar to the situation in HPV8 E6 transgenic mice. We had previously shown that Langerhans cells responsible for epithelial immunosurveillance were strongly reduced at infected sites and that the HPV8 E7 protein interferes with the CCAAT/enhancer-binding protein (C/EBP)β to suppress the Langerhans cell chemokine CCL20. Human papillomavirus type 8 (HPV8), a cutaneous genus beta HPV type, has co-carcinogenic potential at sun-exposed sites in patients suffering from the inherited skin disease epidermodysplasia verruciformis (EV). 8Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarbrücken, Germany.7Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.6Jose Carreras Center for Immune and Gene Therapy, Saarland University Medical Center, Homburg, Germany.5Department of Dermatology, Saarland University Medical Center, Homburg, Germany.4Department of Urology and Pediatric Urology, Saarland University Medical Center, Homburg, Germany.3Institute of Pathology, University of Cologne, Cologne, Germany.2Institute of Virology, University of Cologne, Cologne, Germany.1Institute of Virology, Saarland University Medical Center, Homburg, Germany.Luca Vella 1 Anna Sternjakob 1 Stefan Lohse 1 Alina Fingerle 1 Tanya Sperling 2 Claudia Wickenhauser 3 Michael Stöckle 4 Thomas Vogt 5 Klaus Roemer 6 Monika Ołdak 1,7 Sigrun Smola 1,8*